What is the principle that indicates that after about 50 doublings,cells lose their ability to replicate?

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The principle that indicates that after about 50 doublings, cells lose their ability to replicate is known as the Hayflick limit, named after Leonard Hayflick, who discovered this phenomenon in 1961. This is due to telomeres shortening with each cell division, eventually leading to the loss of genetic information and the inability of cells to divide further.

What Is the Principle That Indicates That After About 50