Which of the following is the correct sequence of events leading to the polyuria and dehydration associated with diabetes mellitus?
A) Hyperglycemia → glucose in urine raises osmolarity of tubular fluid → glucose transport maximum exceeded → glucose enters renal tubules → osmotic diuresis
B) Hyperglycemia → glucose enters renal tubules → glucose transport maximum exceeded → glucose in urine raises osmolarity of tubular fluid → osmotic diuresis
C) Hyperglycemia → glucose enters renal tubules → glucose in urine raises osmolarity of tubular fluid → osmotic diuresis → glucose transport maximum exceeded
D) Hyperglycemia → glucose transport maximum exceeded → glucose enters renal tubules → glucose in urine raises osmolarity of tubular fluid → osmotic diuresis
E) Osmotic diuresis → glucose enters renal tubules → glucose transport maximum exceeded → glucose in urine raises osmolarity of tubular fluid → hyperglycemia

Question

Quizplus · Accepted Answer

The correct sequence starts with hyperglycemia, which leads to glucose entering the renal tubules. Once the glucose transport maximum is exceeded, glucose remains in the urine, raising the osmolarity of the tubular fluid and resulting in osmotic diuresis.

Which of the Following Is the Correct Sequence of Events