In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?

Question

Quizplus · Accepted Answer

In sickle-cell anemia, abnormal hemoglobin differs from normal hemoglobin by a single amino acid substitution. Specifically, a valine residue replaces a glutamic acid residue in the beta-globin chain of hemoglobin. This small change affects the shape of the red blood cells, leading to their characteristic sickle shape and a range of health problems. Phenylketonuria, cystic fibrosis, hemophilia, and albinism are all caused by mutations in different genes and involve more significant changes to the structure or function of proteins.

In Which Hereditary Disease Does Abnormal Hemoglobin Differ from Normal