Which Assessment Findings Would the Nurse Evaluate as Indicating Substance

Which assessment findings would the nurse evaluate as indicating substance dependence?. Select all that apply.

A) The patient is exhibiting tolerance.
B) The patient spends significant amounts of time trying to obtain the substance.
C) The patient continues to use the substance after acknowledging it is not good for his health.
D) The patient describes several attempts to control substance use.
E) The patient continues to use the substance in spite of serious relationship problems.