A protein is known to be stabilized by a salt bridge between a lysine at position 26 and an aspartic acid at position 108 in the protein's amino acid sequence.When the protein is mutated to substitute a glutamic acid in place of aspartic acid at position 108, the protein cannot fold properly and exhibits no biological activity.What likely contributes to the effects of this amino acid substitution on protein folding?

Question

Quizplus · Accepted Answer

The Answer of A protein is known to be stabilized by a salt bridge between a lysine at position 26 and an aspartic acid at position 108 in the protein's amino acid sequence.When the protein is mutated to substitute a glutamic acid in place of aspartic acid at position 108, the protein cannot fold properly and exhibits no biological activity.What likely contributes to the effects of this amino acid substitution on protein folding?

A Protein Is Known to Be Stabilized by a Salt