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People Born with the Genetic Disorder Known as Glycogen Storage

Question 226

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People born with the genetic disorder known as glycogen storage disease have impaired glycogen synthase.Glycogen synthase is the protein that catalyzes the polymerization of glucose to form glycogen.Affected people exhibit extreme tiredness and poor muscle function upon developing very low blood sugar levels when they have not eaten in a while.They show improvements soon after taking in food, which boosts their blood sugar concentrations.If the cells of these patients cannot polymerize glucose into glycogen, why don't the cells simply store excess glucose monomers for use during times between meals?


A) The accumulation of large numbers of glucose monomers would upset the osmotic balance of cells in a way that glycogen does not.
B) A large number of glucose monomers would take up much more space inside cells than glycogen made from an equivalent number of monomers.
C) Glucose monomers would have no way to move back across the cell membrane once they entered a cell.
D) The cells would immediately metabolize all of the glucose monomers, creating very large amounts of heat that would destroy the cells.
E) The large number of glucose monomers would begin reacting with other molecules in the cell, causing disruption of normal metabolic reactions.

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