Consider the following double-stranded DNA region:
5ʹ-TGCCAT-3ʹ
3ʹ-ACGGTA-5ʹ
If the lower strand is transcribed, which strand will result?
A) TGCCAT
B) TCGGTA
C) UGCCAU
D) UGCCUA
E) TCGGUT

Question

Consider the following double-stranded DNA region: 
5ʹ-TGCCAT-3ʹ
3ʹ-ACGGTA-5ʹ
If the lower strand is transcribed, which strand will result?
A) TGCCAT
B) TCGGTA
C) UGCCAU
D) UGCCUA
E) TCGGUT

Quizplus · Accepted Answer

Transcription involves the synthesis of RNA from a DNA template, where RNA base pairing with DNA bases occurs. Several rules need to be considered when transcribing DNA to RNA. Adenine from DNA pairs with uracil (U) in RNA, thymine (T) from DNA pairs with Adenine in RNA, Guanine from DNA pairs with cytosine (C) in RNA, and cytosine from DNA pairs with Guanine in RNA.

Therefore, when the lower DNA strand is transcribed, the resulting RNA is 5ʹ-UGCCAU-3ʹ (C pairs with G, G pairs with C, and A pairs with U). So, the correct answer is C: UGCCAU.

Consider the Following Double-Stranded DNA Region