Refer to the figure below showing the process of receptor-mediated endocytosis. Which statement regarding this process is false?
A) Receptor-mediated endocytosis involves receptor proteins located on the cell's surface.
B) Coated pits are lined on their cytoplasmic surface by clathrin.
C) Receptor-mediated endocytosis is important in cellular uptake of cholesterol.
D) Coated vesicles eventually become part of the endoplasmic reticulum.
E) Coated vesicles contain materials that were previously extracellular.

Question

Refer to the figure below showing the process of receptor-mediated endocytosis.  Which statement regarding this process is false?
A) Receptor-mediated endocytosis involves receptor proteins located on the cell's surface. 
B) Coated pits are lined on their cytoplasmic surface by clathrin. 
C) Receptor-mediated endocytosis is important in cellular uptake of cholesterol. 
D) Coated vesicles eventually become part of the endoplasmic reticulum. 
E) Coated vesicles contain materials that were previously extracellular.

Quizplus · Accepted Answer

Coated vesicles do not become part of the endoplasmic reticulum, rather they fuse with endosomes, a type of membrane-bound compartment in the cytoplasm where the receptor and ligand dissociate. The uncoated vesicles then fuse with lysosomes, where their contents are degraded by hydrolytic enzymes.

Refer to the Figure Below Showing the Process of Receptor-Mediated