Refer to the table below. A pharmaceutical company is developing five new drugs to act as antagonists with respect to five different receptor proteins.Listed in the table are dissociation constants for ligand and drug in each case.In which case will the dosage of drug necessary to achieve a biological effect be the smallest?
A) A
B) B
C) C
D) D
E) E

Question

Refer to the table below.  A pharmaceutical company is developing five new drugs to act as antagonists with respect to five different receptor proteins.Listed in the table are dissociation constants for ligand and drug in each case.In which case will the dosage of drug necessary to achieve a biological effect be the smallest?
A) A 
B) B 
C) C 
D) D 
E) E

Quizplus · Accepted Answer

The smaller the dissociation constant, the stronger the drug binds to the receptor, meaning a lower dosage is needed to achieve a biological effect. Therefore, case A with the lowest dissociation constant for both ligand and drug will require the smallest dosage of drug.

Refer to the Table Below