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Adrenocorticotropic Hormone (ACTH) Is a Peptide Consisting of 39 Amino

Question 114

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Adrenocorticotropic hormone (ACTH) is a peptide consisting of 39 amino acids.When the arginine residue at position 8 in the peptide chain is replaced with cysteine, the peptide no longer activates signal transduction in cells containing ACTH receptors.Explain why a single change in amino acid identity in ACTH has this result.

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The ACTH molecule must assume a particul...

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