Refer to the table below. The table summarizes results of experiments using a group of normal cells and three other groups of the same type of cells, each carrying a different mutation in a membrane receptor protein.The receptor is part of a signal transduction pathway that is stimulated by glucose-6-phosphate.Cells were tested for their ability to respond, via the signal transduction pathway, to a variety of ligand molecule, as shown in the table.Based on these data, which statement about these three mutations is plausible?
A) Mutations 1, 2, and 3 each broaden the specificity of ligand binding in different ways.
B) Mutations 1 and 3 broaden the specificity of ligand binding, while mutation 2 eliminates ligand binding.
C) Mutation 1 broadens the specificity of ligand binding, while mutations 2 and 3 eliminate ligand binding.
D) Mutation 3 has no effect on ligand binding, while mutations 1 and 2 have dramatic effects on ligand binding.
E) Mutations 1 and 3 have no effect on ligand binding, while mutation 2 has a dramatic effect on ligand binding.

Question

Refer to the table below.  The table summarizes results of experiments using a group of normal cells and three other groups of the same type of cells, each carrying a different mutation in a membrane receptor protein.The receptor is part of a signal transduction pathway that is stimulated by glucose-6-phosphate.Cells were tested for their ability to respond, via the signal transduction pathway, to a variety of ligand molecule, as shown in the table.Based on these data, which statement about these three mutations is plausible?
A) Mutations 1, 2, and 3 each broaden the specificity of ligand binding in different ways. 
B) Mutations 1 and 3 broaden the specificity of ligand binding, while mutation 2 eliminates ligand binding. 
C) Mutation 1 broadens the specificity of ligand binding, while mutations 2 and 3 eliminate ligand binding. 
D) Mutation 3 has no effect on ligand binding, while mutations 1 and 2 have dramatic effects on ligand binding. 
E) Mutations 1 and 3 have no effect on ligand binding, while mutation 2 has a dramatic effect on ligand binding.

Quizplus · Accepted Answer

The table shows that for mutation 1 and 3, there are more ligands that activate the pathway compared to the normal cells, suggesting a broader specificity of ligand binding. For mutation 2, there are no ligands that activate the pathway, indicating elimination of ligand binding. Therefore, statement B is the most plausible explanation. The other statements do not accurately reflect the data in the table.

Refer to the Table Below