Which statement about G protein-coupled receptors is false?
A) Each receptor has seven transmembrane regions.
B) They are involved in light and odor detection.
C) They have an extracellular side and a cytoplasmic region.
D) Their ligands bind to the cytoplasmic region, which also binds to a G protein.
E) Ligand binding changes the shape of the G protein attached to the receptor.

Question

Quizplus · Accepted Answer

G protein-coupled receptors (GPCRs) have their ligands bind to the extracellular side, not the cytoplasmic region. The cytoplasmic region is where the G protein binds and is activated upon receptor-ligand interaction, leading to a conformational change in the G protein.

Which Statement About G Protein-Coupled Receptors Is False