The Phosphorylation of Glucose to Glucose 6-Phosphate Is a Reaction $\Delta$

The phosphorylation of glucose to glucose 6-phosphate is a reaction with a $\Delta$ G of +4.0 kcal/mol.What is required for this reaction to take place?

A) The input of energy from hydrolysis of ATP
B) An increase in glucose concentration to push the reaction toward the product
C) The coupling of this reaction with an endergonic reaction
D) The addition of a noncompetitive inhibitor
E) Nothing is required; this is a spontaneous reaction.