The addition of the competitive inhibitor mevinolin slows the reaction
HMG-CoA$\rightarrow$ mevalonate, which is catalyzed by the enzyme HMG-CoA reductase.In order to overcome the effects of mevinolin and increase the rate of the reaction, you would

Question

The addition of the competitive inhibitor mevinolin slows the reaction 
HMG-CoA$\rightarrow$ mevalonate, which is catalyzed by the enzyme HMG-CoA reductase.In order to overcome the effects of mevinolin and increase the rate of the reaction, you would

Quizplus · Accepted Answer

The addition of more substrate (HMG-CoA) would increase the likelihood of it binding to the active site of the enzyme, effectively outcompeting the inhibitor and increasing the rate of the reaction. Adding more of the product (mevalonate) would not overcome the effects of the inhibitor, as the inhibitor binds to the enzyme rather than the product. Lowering the temperature or rate constant would decrease the rate of the reaction, not increase it. Adding a prosthetic group may enhance the activity of the enzyme, but it would not directly overcome the effects of the inhibitor.

The Addition of the Competitive Inhibitor Mevinolin Slows the Reaction →\rightarrow→

The Addition of the Competitive Inhibitor Mevinolin Slows the Reaction $\rightarrow$