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Two Amino Acids Shown to Be Essential in the Catalytic

Question 108

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Two amino acids shown to be essential in the catalytic mechanism of phosphohexose isomerase are a histidine and a lysine.These two side chains work together in a reversible series of protonation and deprotonation steps to break one bond in the substrate and form a new one.This is an example of a(n) _______ mechanism of catalysis.

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