In the citric acid cycle, isocitrate dehydrogenase is regulated in part by the supply and demand of downstream products of cellular respiration and metabolism.Which product acts as an allosteric inhibitor of isocitrate dehydrogenase activity?

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NADH acts as an allosteric inhibitor of isocitrate dehydrogenase activity. When the concentration of NADH is high, it indicates that the cells have sufficient energy and do not require further production of ATP through the citric acid cycle. As a result, NADH binds to isocitrate dehydrogenase and inhibits its activity, slowing down the cycle. This helps to prevent the buildup of metabolic intermediates and conserve cellular resources.

In the Citric Acid Cycle, Isocitrate Dehydrogenase Is Regulated in Part