Some poisons are compounds that interfere with metabolic pathways.Which poison would interfere with the citric acid cycle but not affect glycolysis?

Question

Quizplus · Accepted Answer

The citric acid cycle (also known as the Krebs cycle) takes place in the mitochondria and is responsible for generating ATP through the oxidation of acetyl-CoA. Pyruvate dehydrogenase is the enzyme responsible for converting pyruvate to acetyl-CoA, which then enters the citric acid cycle. Therefore, a compound that inhibits pyruvate dehydrogenase would interfere with the citric acid cycle but not affect glycolysis. Accelerating ATP hydrolysis, inhibiting regeneration of NADH, accelerating coenzyme A synthesis, or accelerating pyruvate oxidation would likely affect both glycolysis and the citric acid cycle.

Some Poisons Are Compounds That Interfere with Metabolic Pathways