Which statement does not support Garrod's hypothesis that inborn errors of metabolism cause disease?
A) The disease PKU is due to failure to produce a functional variant of an enzyme.
B) A blood disease is due to a recessive allele in a single gene.
C) A neurological disease is due to a dominant allele in a single gene.
D) Multiple genes contribute to the likelihood that a person will develop coronary heart disease.
E) Supplying a patient with a missing enzyme can alleviate the symptoms of a metabolic disease.

Question

Quizplus · Accepted Answer

Choice D states that multiple genes contribute to the likelihood of developing a disease, which goes against Garrod's hypothesis that inborn errors of metabolism (caused by a single gene) are responsible for all genetic diseases. The other statements either support or are neutral towards Garrod's hypothesis.

Which Statement Does Not Support Garrod's Hypothesis That Inborn Errors