Chronic myelogenous leukemia (CML) is usually caused by the oncogene BCR/ABL.This abnormal gene is the product of the fusion of part of a BCR gene with part of an ABL gene.The resulting protein has unregulated tyrosine kinase activity.The BCR and ABL genes are normally found on two different chromosomes, respectively 22 and 9.What type of mutation is required to generate the BCR/ABL fusion gene?
A) Chromosomal inversions
B) Chromosomal deletion
C) Chromosomal transversions
D) Chromosomal transitions
E) Chromosomal translocation

Question

Quizplus · Accepted Answer

The fusion of BCR gene with ABL gene requires a chromosomal translocation, which is an event during which two chromosomes exchange segments or part of their genetic material. In the case of chronic myelogenous leukemia, this results in the fusion of the two genes on chromosome 9 and 22, respectively, producing the BCR/ABL fusion gene. Chromosomal inversions, deletions, transversions, or transitions do not involve the exchange of segments between chromosomes and would not generate the BCR/ABL fusion gene.

Chronic Myelogenous Leukemia (CML) Is Usually Caused by the Oncogene