A disease that manifests itself in symptoms of neurodegeneration is passed down from generation to generation in a manner consistent with an autosomal dominant mutation.The symptoms tend to get worse in subsequent generations, with individuals showing symptoms at progressively earlier ages than their afflicted parents.What is the most reasonable hypothesis consistent with all of these facts?

Question

Quizplus · Accepted Answer

This is consistent with the symptoms worsening and appearing at earlier ages in subsequent generations, as well as the autosomal dominant inheritance pattern. An expanding triplet repeat could lead to increased severity of the disease with each generation, as seen in disorders such as Huntington's disease.

Option A is not likely as reciprocal translocations are not usually associated with neurodegenerative diseases. Option B is not consistent with the autosomal dominant inheritance pattern. Option D is not possible as a loss-of-function mutation would likely not result in neurodegeneration. Option E is also not likely as transposons are not typically associated with neurodegenerative diseases.

A Disease That Manifests Itself in Symptoms of Neurodegeneration Is