Which disease involves an expanding triplet repeat?
A) Sickle-cell disease
B) Huntington's disease
C) Duchenne muscular dystrophy
D) Most cancers
E) PKU

Question

Quizplus · Accepted Answer

Huntington's disease involves an expansion of the CAG triplet repeat in the Huntingtin gene. This can lead to abnormal protein accumulation in the brain and cause symptoms such as involuntary movements and cognitive impairment. Sickle-cell disease is caused by a single amino acid substitution in the beta-globin protein, Duchenne muscular dystrophy is caused by mutations in the DMD gene, cancer is a collection of diseases with various genetic and environmental causes, and PKU is caused by mutations in the PAH gene.

Which Disease Involves an Expanding Triplet Repeat