Which Scenario Is Representative of a Multifactorial Disease

Which scenario is representative of a multifactorial disease?

A) The gene responsible for the disease contains a triplet sequence, CGG, in the promotor region, which is repeated 500 times.
B) There is loss of function of a normal tumor suppressor gene, followed by abnormal cell growth, activation of an oncogene, continued abnormal cell growth, and loss of function of additional tumor suppressor genes, ultimately leading to cancer.
C) Parts of chromosomes 10 and 19 are swapped (translocated) , and as a result, gene A on chromosome 10 becomes fused with gene B on chromosome 19, resulting in a gain-of-function mutation causing uncontrolled cell division.
D) A point mutation leading to a frame-shift mutation in gene A results in the production of a nonfunctional protein.
E) A chromosome breaks at two points and then rejoins, leaving out the DNA between the breaks, thus resulting in a deletion of gene A.