If a disease is due to a completely dominant mutation, the DNA of individuals that hybridize both normal and disease probes in allele-specific oligonucleotide hybridization should _______.If a disease is due to a completely recessive mutation, the DNA samples of individuals that hybridize both normal and disease probes in this test should _______.

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In the case of a completely dominant mutation, individuals who hybridize both normal and disease probes are heterozygous, meaning they carry one normal allele and one disease allele. Because the mutation is dominant, having just one copy of the disease allele is enough to exhibit the disease. For a completely recessive mutation, individuals must have two copies of the disease allele to exhibit the disease. Those who hybridize both normal and disease probes are also heterozygous in this scenario but do not exhibit the disease because they have one normal allele that is sufficient to prevent the disease phenotype.

If a Disease Is Due to a Completely Dominant Mutation