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A Couple Are Heterozygous for Tay-Sachs, a Rare Autosomal Recessive

Question 237

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A couple are heterozygous for Tay-Sachs, a rare autosomal recessive disease that is fatal in infancy and results when a baby inherits two nonfunctional alleles of HEXA, the gene for the enzyme hexosaminidase A.The couple wants to ensure that the mother only becomes pregnant with a fertilized egg that is homozygous HEXA normal.A _______ screening test would best ensure that she did not become pregnant with another HEXA genotype.

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