Consider the following statement: Histone deacetylases tend to decrease transcription from particular genes.Is it true or false, and for what reason?
A) True, because acetylated histones have higher affinity for DNA
B) True, because acetylated histones have lower affinity for DNA
C) False, because acetylated histones have higher affinity for DNA
D) False, because acetylated histones have lower affinity for DNA
E) False, because acetylation status of histones has no bearing on transcription

Question

Quizplus · Accepted Answer

Histone deacetylases remove acetyl groups from lysine residues on histone proteins, leading to a more condensed chromatin structure that tends to inhibit transcription. This occurs because acetylation of histones weakens their interaction with DNA, making the DNA more accessible to transcription factors and RNA polymerase. Therefore, decreasing acetylation levels with histone deacetylases tends to result in decreased transcription from particular genes.

Consider the Following Statement: Histone Deacetylases Tend to Decrease Transcription