A mutation causes an increase in the activity of histone deacetylase.Most likely, histones will have _______ affinity to DNA, and there will be a(n) _______ in transcription.

Question

Quizplus · Accepted Answer

Histone deacetylase removes acetyl groups from histones, which causes the histones to have a greater affinity to DNA. This tighter packing of DNA inhibits transcription, so an increase in histone deacetylase activity would cause a decrease in transcription.

A Mutation Causes an Increase in the Activity of Histone