Which techniques, tools, or activities would be most directly useful in identifying the genetic variants associated with a complex human disease such as schizophrenia?
A) Haplotype mapping
B) Selective inactivation
C) Metagenomics
D) Determining the metabolome
E) Performing a pseudogene screen

Question

Quizplus · Accepted Answer

Haplotype mapping is a technique that can be used to identify regions of the genome that are associated with a disease. Since schizophrenia is a complex disease, it is likely caused by multiple genetic variants, and haplotype mapping can help identify these variants.

Answer: B
 Selective inactivation is a technique that involves selectively turning off certain genes in cells to determine their function. This technique can be useful in identifying genes that are associated with schizophrenia by turning off genes that are suspected to be involved in the disease and observing the effects on cellular function.

Answer: E
 Performing a pseudogene screen involves sequencing the genome to identify pseudogenes, which are non-functional copies of genes that have been mutated over time. Pseudogenes can be used to identify genetic variations that may be associated with complex diseases like schizophrenia.

Which Techniques, Tools, or Activities Would Be Most Directly Useful