Which statement about DNA sequencing is false?
A) The method developed by Sanger in the 1970s involved chemical modifications of bases.
B) The method developed by Sanger in the 1970s involved breaking up the DNA molecule into numerous small fragments.
C) High-throughput methods involve starting at one end of the chromosome and simply sequencing the DNA molecule one nucleotide at a time.
D) High-throughput methods rely on miniaturization techniques first developed for the electronics industry.
E) High-throughput sequencing is generally faster than Sanger sequencing.

Question

Quizplus · Accepted Answer

High-throughput methods do not involve sequencing the entire chromosome one nucleotide at a time. Rather, these methods involve breaking the DNA into small fragments, sequencing them simultaneously, and then computationally assembling the fragments into a complete sequence.

Which Statement About DNA Sequencing Is False