The Voltage-Gated Sodium Channels of Neurons Are Membrane Proteins That

The voltage-gated sodium channels of neurons are membrane proteins that play a fundamental role in the generation of action potentials.Blockage of their activity by toxins, such as tetrodoxin, causes paralysis.To determine which nucleotides confer resistance to tetrodoxin in puffer fish and other resistant animals, researchers can _______ the sodium channel genes of resistant and nonresistant animals.

A) map the missense mutations of
B) map the sequence deletions within
C) determine the rate of genetic drift within
D) quantify the number of gene duplications within
E) compare the rates of synonymous and nonsynonymous nucleotide substitutions within