Which General Principle of Molecular Evolution Can You Most Reasonably

Which general principle of molecular evolution can you most reasonably infer?

A) Most natural populations harbor far less genetic variation than we would expect to find if genetic variation were influenced by natural selection alone.
B) The rate at which genetic changes evolve is positively correlated with how much phenotypic change they cause.
C) The rate at which genetic changes evolve is negatively correlated with how much phenotypic change they cause.
D) Most mutations are advantageous.
E) Natural selection is most efficient when population sizes are small.