A pharmaceutical company is working on development of a drug that will broadly target diseases caused by trypanosomes.The most effective drug would be one that
A) binds to molecules on their cell surface, preventing entry into the human host.
B) that binds to molecules on their cell surface, blocking proliferation by asexual reproduction.
C) binds to the kinetoplast, preventing mRNA editing in the mitochondrion.
D) that will prevent mitosis from occurring.
E) that targets insects, and can be used to eliminate tsetse flies.

Question

Quizplus · Accepted Answer

Trypanosomes rely heavily on mRNA editing in their mitochondria for survival, making a drug that interferes with this process an effective target. Additionally, drugs that target the cell surface or proliferation may have reduced efficacy due to the trypanosome's ability to evade the immune system and rapidly evolve resistance to drugs. Preventing mitosis or targeting insects may also have unintended consequences or be less effective in controlling disease transmission.

A Pharmaceutical Company Is Working on Development of a Drug