Which Statement About Transmembrane Glycoprotein Complexes Is False

Which statement about transmembrane glycoprotein complexes is false?

A) The cytoplasmic domain initiates the response of the target cell through a second-messenger cascade.
B) The binding domain anchors the receptor in the cell membrane.
C) Signaling cascades generated by these receptors can enter the nucleus and alter gene expression.
D) Second-messenger-activated cascades generated by these receptors eventually activate either protein kinases or protein phosphatases.
E) Signaling cascades generated by these receptors typically alter the activity of enzymes in the cytoplasm, which leads to the cell's response.