Which Statement About Cortisol and Stress Is True

Which statement about cortisol and stress is true?

A) Aging rats show increased ability to turn off stress responses and retain the ability to turn on stress responses.
B) The hypothalamus loses cortisol-sensitive cells in response to prolonged medical use of cortisol, causing decreased ability to turn off stress responses.
C) Cortisol production decreases dramatically in rats as they age.
D) Stress responses are turned back on by the negative feedback action of cortisol on the hypothalamus.
E) The hypothalamus increases cortisol-sensitive cells in response to repeated stress, causing increased ability to turn off stress responses.