Epinephrine Can Cause Different Responses in Different Organs

Epinephrine can cause different responses in different organs.There can be a variety of reasons for this.Of those listed, which is the most likely?

A) Different organs can have different receptors that cause different cell responses.
B) Different receptors in different organs may activate the same enzymes.
C) The hormone changes its conformation prior to binding to different organs.
D) The specific response is determined by the number of receptors present.
E) The specific response is determined by whether the hormone enters the cell or binds to the cell surface.