If you were to design a vaccine to prevent infection from a mucosal pathogen such as Vibrio cholerae, which antibody class do you think would be most effective in preventing colonization in the intestinal tract?

Question

Quizplus · Accepted Answer

IgA is the most effective antibody class in preventing colonization by mucosal pathogens. It is secreted at mucosal surfaces such as the intestinal tract, where it prevents pathogens from attaching and colonizing. IgA also acts as a neutralizing antibody, preventing pathogens from causing harm to host cells. IgG, IgM, IgD, and IgE are less effective in preventing mucosal infections.

If You Were to Design a Vaccine to Prevent Infection