In the vertebrate neuromuscular junction, acetylcholine is transmitted from the presynaptic neuron to the postsynaptic motor end plate through

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Acetylcholine is transmitted from the presynaptic neuron to the postsynaptic motor end plate through diffusion. When an action potential arrives at the presynaptic terminal, it opens voltage-gated Ca2+ channels causing an influx of Ca2+. This leads to the fusion of acetylcholine-containing vesicles with the presynaptic membrane, releasing acetylcholine into the synaptic cleft. Acetylcholine then diffuses across the cleft and binds to nicotinic acetylcholine receptors on the postsynaptic motor end plate, triggering an action potential in the postsynaptic muscle cell.

In the Vertebrate Neuromuscular Junction, Acetylcholine Is Transmitted from the Presynaptic