The loop of Henle functions as a countercurrent multiplier mechanism.In this context, "countercurrent" refers to the flow of filtrate in opposite directions in the descending and ascending limbs of the Loop of Henle, and "multiplier" refers to the

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The countercurrent multiplier mechanism refers to the exchange between the descending and ascending limbs of the Loop of Henle, which creates a concentration gradient in the interstitial fluid of the medulla. As water flows out of the descending limb and into the more concentrated interstitial fluid, it creates a gradient that drives solute transport out of the ascending limb and into the interstitial fluid. This process is amplified as the filtrate flows through the loop, generating a concentration gradient that allows for the reabsorption of more water and solutes. This mechanism is critical for the production of concentrated urine in mammals.

The Loop of Henle Functions as a Countercurrent Multiplier Mechanism