A neoplastic malignancy of the lymphatic system characterized by painless enlargement of the lymph nodes and spleen is called:

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Hodgkin disease is a neoplastic malignancy of the lymphatic system that presents with painless enlargement of the lymph nodes and spleen. Lymphosarcoma refers to a lymphatic malignancy that arises from lymphatic tissues outside the lymph nodes, while lymphedema refers to the swelling caused by accumulation of lymphatic fluid. Chronic leukemia is a neoplastic malignancy of the blood-forming cells.

A Neoplastic Malignancy of the Lymphatic System Characterized by Painless