A chronic skeletal disease characterized by an initial phase of a high rate of bone turnover is:

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Osteitis deformans, also known as Paget's disease, is a chronic skeletal disease characterized by an initial phase of a high rate of bone turnover, leading to excessive breakdown and formation of bone tissue. This results in the affected bone becoming dense, enlarged, and deformed. It primarily affects the elderly, and symptoms include bone pain, deformities, fractures, and hearing loss. The other options listed do not involve a high rate of bone turnover as a primary characteristic.

A Chronic Skeletal Disease Characterized by an Initial Phase of a High