Capsaicin rubs, Tiger balm, and other salves used by athletes to sooth muscle injuries create a burning sensation. This is likely due to the fact that the skin receptors they affect signal the release of ____________ that eventually prevents the affected neurons from transmitting pain signals.

Question

Quizplus · Accepted Answer

Capsaicin and other salves used by athletes contain compounds that bind to and activate the TRPV1 receptor on the skin. This receptor is normally activated by heat, which is why the skin feels like it's burning. When TRPV1 is activated, it causes a release of substance P, which signals pain to the brain. However, if the TRPV1 receptor is constantly activated by capsaicin or other compounds, it eventually leads to depletion of substance P, which in turn prevents the affected neurons from transmitting pain signals.

Capsaicin Rubs, Tiger Balm, and Other Salves Used by Athletes