The sickle-cell gene is often fatal to those who __________.

Question

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Sickle-cell disease occurs when an individual inherits two copies of the sickle-cell gene (one from each parent). Inheriting the gene from only one parent can result in sickle-cell trait, which is usually not fatal. The gene's prevalence and severity are linked to regions of malarial endemicity; people who inherit the sickle-cell gene in regions where malaria is prevalent receive some protection against the disease. Warm regions of the globe tend to have more incidences of malaria but are not the direct cause of sickle cell disease.

The Sickle-Cell Gene Is Often Fatal to Those Who __________