Orally administered drugs are ingested at higher than needed doses because some of the drug will not make it through the bloodstream.

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When a drug is orally administered, it must first pass through the digestive system, where some of the drug may be metabolized or excreted before it reaches the bloodstream. To compensate for this first-pass effect, the drug is often given at a higher dose than what may be needed to ensure a therapeutic concentration of the drug in the bloodstream.

Orally Administered Drugs Are Ingested at Higher Than Needed Doses