The clearest example of tolerance to the effect of caffeine is observed with respect to __________.

Question

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Studies have shown that regular caffeine consumption can lead to tolerance for the cardiovascular effects of the drug, specifically increased blood pressure and heart rate. This means that individuals who regularly consume caffeine may not experience as strong of a cardiovascular response compared to those who consume caffeine infrequently or for the first time. Tolerance to caffeine's other effects, such as behavioral or psychological responses, may not be as clear.

The Clearest Example of Tolerance to the Effect of Caffeine