With respect to tolerance and dependence, most of the evidence suggests that with chronic use of tricyclic antidepressants
A)tolerance to their antidepressant properties does not develop
B)abrupt drug cessation may precipitate malaise, chills, muscle aches, and hypercholinergic-type effects
C)abrupt cessation of their use does not induce depression
D)all of the above

Question

Quizplus · Accepted Answer

Tricyclic antidepressants, when used chronically, do not typically lead to tolerance of their antidepressant effects, meaning their efficacy does not diminish over time. Abrupt cessation can lead to withdrawal symptoms such as malaise, chills, muscle aches, and effects associated with increased cholinergic activity, but it does not typically induce depression. Therefore, all the statements provided are correct regarding the chronic use of tricyclic antidepressants.

With Respect to Tolerance and Dependence, Most of the Evidence