What was the major reason for lithium's slow acceptance by psychiatrists in the U.S.as a treatment for affective disorders?

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The major reason for lithium's slow acceptance by psychiatrists in the US as a treatment for affective disorders was its toxicity. Lithium has a narrow therapeutic index and can cause serious side effects, especially when taken in large doses. This made psychiatrists hesitant to use it as a treatment option, despite its effectiveness in some patients.

What Was the Major Reason for Lithium's Slow Acceptance by Psychiatrists