If a drug blocks dopamine receptors and those receptors are located on both postsynaptic and presynaptic neurons, what would be the initial effect of the drug on levels of dopamine in the synaptic cleft?

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Quizplus · Accepted Answer

Blocking dopamine receptors, especially on presynaptic neurons, can lead to an increase in dopamine levels in the synaptic cleft initially. This is because the presynaptic receptors (autoreceptors) typically act to regulate neurotransmitter release through negative feedback mechanisms. When these receptors are blocked, the feedback inhibition is reduced, leading to increased release of dopamine into the synaptic cleft.

If a Drug Blocks Dopamine Receptors and Those Receptors Are