What is a theoretical basis for the use of tricyclic antidepressants like desipramine in the treatment of cocaine dependence?

Question

Quizplus · Accepted Answer

The Answer is One of the underlying motivating factors behind cocaine use may be endogenous depression or depression resulting from cocaine abuse.Since tricyclics may reduce the depression, they may reduce the motivation to use cocaine.Also, desipramine theoretically reduces the uptake of monoamines, similar to cocaine's actions, and thus may reduce the craving associated with reduced monoamine activity.

What Is a Theoretical Basis for the Use of Tricyclic