Research with nonhuman subjects suggests that sensitization to the psychosis-mimicking effects of cocaine is most likely to occur with

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Research with nonhuman subjects suggests that sensitization to the psychosis-mimicking effects of cocaine is most likely to occur with intermittent exposure to high doses of cocaine. This means that repeated exposure to high doses of cocaine can lead to an increased sensitivity to its effects, which can result in psychosis-like symptoms. Conversely, intermittent exposure to sub-threshold doses is unlikely to cause sensitization, and fairly continuous exposure to moderate doses is less likely to cause sensitization than intermittent exposure to high doses.

Research with Nonhuman Subjects Suggests That Sensitization to the Psychosis-Mimicking