The use of antidepressants in the treatment of cocaine addiction is based primarily on the hypothesis that these drugs

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Antidepressants may decrease the symptoms of depression that may predispose the individual to use cocaine to "self-medicate" themselves. Although antidepressants may have some effects on cocaine use (such as inhibiting the euphoric properties of cocaine), their primary use in treating cocaine addiction is to address any underlying mental health conditions that may be contributing to the addiction.

The Use of Antidepressants in the Treatment of Cocaine Addiction