If two drugs exert the same pharmacodynamic actions but differ in terms of their pharmacokinetic properties, which of the drugs is likely to produce the most intense abstinence symptoms after chronic use? The drug with the
A)shortest duration of action
B)longest duration of action
C)slowest passage through the blood brain barrier
D)longest times between drug exposures

Question

Quizplus · Accepted Answer

The drug with the shortest duration of action is likely to produce the most intense abstinence symptoms after chronic use. This is because the drug is quickly metabolized and eliminated from the body, leading to withdrawal symptoms as the body adapts to the absence of the drug. In contrast, a drug with a longer duration of action would continue to exert its effects even after the last dose, reducing the severity of withdrawal symptoms. The passage through the blood-brain barrier and the timing between drug exposures are not directly related to the intensity of abstinence symptoms.

If Two Drugs Exert the Same Pharmacodynamic Actions but Differ